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Article

Flexibility in the Periplasmic Domain of BamA Is Important for Function.

Structure (London, England : 1993) - 3 Jan 2017

Warner Lisa R, Gatzeva-Topalova Petia Z, Doerner Pamela A, Pardi Arthur, Sousa Marcelo C

Abstract excerpt

The β-barrel assembly machine (BAM) mediates the biogenesis of outer membrane proteins (OMPs) in Gram-negative bacteria. BamA, the central BAM subunit composed of a transmembrane β-barrel domain linked to five polypeptide transport-associated (POTRA) periplasmic domains, is thought to bind nascent OMPs and undergo conformational cycling to catalyze OMP folding and insertion. One model is that conformational...

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Identifiers

PMID: 27989620
DOI: 10.1016/j.str.2016.11.013
PMCID: PMC5235167

Genes

OMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Flexibility in the Periplasmic Domain of BamA Is Important for Function.PMID 27989620Read ↗

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