Article
Functionally significant mobile regions of Escherichia coli SecA ATPase identified by NMR.
The Journal of biological chemistry - 27 Dec 2002
Chou Yi-Te, Swain Joanna F, Gierasch Lila M
Abstract excerpt
SecA, a 204-kDa homodimeric protein, is a major component of the cellular machinery that mediates the translocation of proteins across the Escherichia coli plasma membrane. SecA promotes translocation by nucleotide-modulated insertion and deinsertion into the cytoplasmic membrane once bound to both the signal sequence and portions of the mature domain of the preprotein. SecA is proposed to undergo major...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Bacterial Proteins
- Dimerization
- Escherichia coli
- Escherichia coli Proteins
- Genetic Variation
- Magnetic Resonance Spectroscopy
- Membrane Transport Proteins
- Models, Molecular
- Molecular Sequence Data
- Peptide Fragments
- Protein Conformation
- Recombinant Proteins
- SEC Translocation Channels
- SecA Proteins