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Article

Conformation-specific labeling of BamA and suppressor analysis suggest a cyclic mechanism for β-barrel assembly in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 26 Mar 2013

Rigel Nathan W, Ricci Dante P, Silhavy Thomas J

Abstract excerpt

In gram-negative bacteria, integral outer membrane β-barrel proteins (OMPs) are assembled by the beta-barrel assembly machine (Bam) complex. The essential components of this complex are the OMP BamA [which contains a carboxyl-terminal β-barrel and an amino-terminal periplasmic module composed of five polypeptide transport associated (POTRA) domains] and the lipoprotein BamD. In Escherichia coli, the Bam complex...

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Identifiers

PMID: 23479609
DOI: 10.1073/pnas.1302662110
PMCID: PMC3612609

Genes

OMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformation-specific labeling of BamA and suppressor analysis suggest a cyclic mechanism for β-barrel assembly in Escherichia coli.PMID 23479609Read ↗

Conserved residues of the putative L6 loop of Escherichia coli BamA play a critical role in the assembly of β-barrel outer membrane proteins, including that of BamA itself.Semantic proximity Read ↗

Functions of the BamBCDE Lipoproteins Revealed by Bypass Mutations in BamA.Semantic proximity Read ↗

The Structure of a BamA-BamD Fusion Illuminates the Architecture of the β-Barrel Assembly Machine Core.Semantic proximity Read ↗

BamA β16C strand and periplasmic turns are critical for outer membrane protein insertion and assembly.Semantic proximity Read ↗

Substitutions in the BamA β-barrel domain overcome the conditional lethal phenotype of a ΔbamB ΔbamE strain of Escherichia coli.Semantic proximity Read ↗

Lateral opening and exit pore formation are required for BamA function.Semantic proximity Read ↗

The BaeSR two-component system activates bamK, a paralog of the essential β-barrel foldase bamA, in Klebsiella pneumoniae.Semantic proximity Read ↗

Expression, Purification, and Screening of BamE, a Component of the BAM Complex, for Structural Characterization.Semantic proximity Read ↗

Classifying β-Barrel Assembly Substrates by Manipulating Essential Bam Complex Members.Semantic proximity Read ↗

Outer membrane protein assembly mediated by BAM-SurA complexes.Semantic proximity Read ↗

Flexibility in the Periplasmic Domain of BamA Is Important for Function.Semantic proximity Read ↗

Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM.Semantic proximity Read ↗

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