Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinicopathological features of a kindred with SCG5-GREM1-associated hereditary mixed polyposis syndrome.

Human pathology - 1 Feb 2017

Plesec Thomas, Brown Kathryn, Allen Charles, A Burke Carol, Church James, Kalady Matthew, LaGuardia Lisa, O'Malley Margaret, Heald Brandie

Abstract excerpt

Since first characterized in 1997, patients with hereditary mixed polyposis syndrome (HMPS) have been difficult to identify because of lack of well-established diagnostic criteria. Recently, HMPS was found to be caused by a duplication on chromosome 15 spanning the 3' end of the SCG5 gene and a region upstream of the GREM1 locus. Clinical testing for the duplication is available; however, the clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Colonic Polyps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonoscopy

Share to Databases, Factual

Share to Gene Duplication

Share to Gene Fusion

Share to Heredity

Source

Identifiers

PMID: 27984123
DOI: 10.1016/j.humpath.2016.10.002

Genes

GREM1
SCG5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinicopathological features of a kindred with SCG5-GREM1-associated hereditary mixed polyposis syndrome.PMID 27984123Read ↗

Defining the polyposis/colorectal cancer phenotype associated with the Ashkenazi GREM1 duplication: counselling and management recommendations.Semantic proximity Read ↗

Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance.Semantic proximity Read ↗

A prospective study of the clinical, genetic, screening, and pathologic features of a family with hereditary mixed polyposis syndrome.Semantic proximity Read ↗

Clinical and molecular features of the hereditary mixed polyposis syndrome.Semantic proximity Read ↗

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.Semantic proximity Read ↗

Identification of a novel GREM1 duplication in a patient with multiple colon polyps.Semantic proximity Read ↗

Genomic characterization of therapy-associated polyposis reveals an alkylating mutational signature from prior treatmentSemantic proximity Read ↗

Hereditary mixed polyposis syndrome--own experience.Semantic proximity Read ↗

Is the phenotype mixed or mistaken? Hereditary nonpolyposis colorectal cancer and hyperplastic polyposis syndrome.Semantic proximity Read ↗

Colonic polyposis and neoplasia in Cowden syndrome.Semantic proximity Read ↗

Germline variants in Hamartomatous Polyposis Syndrome-associated genes from patients with one or few hamartomatous polypsSemantic proximity Read ↗

Germline bone morphogenesis protein receptor 1A mutation causes colorectal tumorigenesis in hereditary mixed polyposis syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.