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Article

Defining the polyposis/colorectal cancer phenotype associated with the Ashkenazi GREM1 duplication: counselling and management recommendations.

Genetics research - 7 Mar 2016

Ziai James, Matloff Ellen, Choi Jaehyuk, Kombo Ninani, Materin Miguel, Bale Allen E

Abstract excerpt

Hereditary mixed polyposis is a genetically heterogeneous, autosomal dominant condition with adenomatous, hyperplastic and juvenile polyps. We conducted a comprehensive clinical evaluation of a large Ashkenazi Jewish family with this phenotype and performed extensive genetic testing. As seen in one previous report, a 40 kb duplication upstream of GREM1 segregated with the polyposis/colon cancer phenotype in this...

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Identifiers

PMID: 26947005
DOI: 10.1017/S0016672316000021
PMCID: PMC6865171

Genes

GREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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