Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a novel GREM1 duplication in a patient with multiple colon polyps.

Familial cancer - 1 Jan 2019

McKenna Danielle B, Van Den Akker Jeroen, Zhou Alicia Y, Ryan Lauren, Leon Annette, O'Connor Robert, Shah Payal D, Rustgi Anil K, Katona Bryson W

Abstract excerpt

Hereditary mixed polyposis syndrome (HMPS) is a hereditary syndrome that is characterized by multiple colon polyps of mixed pathologic subtypes and an increased risk for colorectal cancer. A 40 kb duplication in the 5' regulatory region of the GREM1 gene was recently found to be the causal mutation in a subset of Ashkenazi Jewish families with HMPS. Given this discovery, the GREM1 5' regulatory region is now...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Colon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonoscopy

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Gene Duplication

Share to Genetic Testing

Share to Intercellular Signaling Peptides and Proteins

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 29804199
DOI: 10.1007/s10689-018-0090-6
PMCID: PMC6261785

Genes

GREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Identification of a novel GREM1 duplication in a patient with multiple colon polyps.PMID 29804199Read ↗

Defining the polyposis/colorectal cancer phenotype associated with the Ashkenazi GREM1 duplication: counselling and management recommendations.Semantic proximity Read ↗

Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance.Semantic proximity Read ↗

GREM1 germline mutation screening in Ashkenazi Jewish patients with familial colorectal cancer.Semantic proximity Read ↗

GREM1 and POLE variants in hereditary colorectal cancer syndromes.Semantic proximity Read ↗

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1Semantic proximity Read ↗

Clinicopathological features of a kindred with SCG5-GREM1-associated hereditary mixed polyposis syndrome.Semantic proximity Read ↗

A prospective study of the clinical, genetic, screening, and pathologic features of a family with hereditary mixed polyposis syndrome.Semantic proximity Read ↗

Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of <i>BMPR1A</i> loss of functionSemantic proximity Read ↗

Variable Features of Juvenile Polyposis Syndrome With Gastric Involvement Among Patients With a Large Genomic Deletion of BMPR1ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.