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Article

Germline bone morphogenesis protein receptor 1A mutation causes colorectal tumorigenesis in hereditary mixed polyposis syndrome.

The American journal of gastroenterology - 1 Dec 2009

Cheah Peh Yean, Wong Yu Hui, Chau Yuk Ping, Loi Carol, Lim Kiat Hon, Lim Jit Fong, Koh Poh Koon, Eu Kong Weng

Abstract excerpt

OBJECTIVES: Hereditary mixed polyposis syndrome (HMPS) is characterized by polyps of mixed adenomatous/hyperplastic/atypical juvenile histology that are autosomal dominantly inherited and that eventually lead to colorectal cancer (CRC). Although CRC with adenomatous polyps is initiated by inactivating adenomatous polyposis coli (APC), the initiating event of CRC with mixed polyps remains unclear. We aimed to...

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PMID: 19773747
DOI: 10.1038/ajg.2009.542

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