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Article

Rapidly Progressive Frontotemporal Dementia Associated with MAPT Mutation G389R.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Sun Lin, Chen Kathryn, Li Xia, Xiao Shifu

Abstract excerpt

Frontotemporal dementia includes a large spectrum of neurodegenerative disorders. Here, we report the case of a young patient with MAPT mutation G389R, who was 27 years old when he progressively developed severe behavioral disturbances. Initially, he presented with slowly progressive personality change. After 1 year, he exhibited moderate dementia with extrapyramidal and pyramidal symptoms. MRI showed...

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PMID: 27802239
DOI: 10.3233/JAD-160802

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MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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