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Closing the tau loop: the missing tau mutation

21 Aug 2015

Abstract excerpt

Frontotemporal lobar degeneration comprises a group of disorders characterized by behavioural, executive, language impairment and sometimes features of parkinsonism and motor neuron disease. In 1994 we described an Irish-American family with frontotemporal dementia linked to chromosome 17 associated with extensive tau pathology. We named this disinhibition-dementia-parkinsonism-amyotrophy complex. We subsequently...

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PMID: 26297556
DOI: 10.1093/brain/awv234

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