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Article

Biosynthetic Origin of the Ether Ring in Platensimycin.

Journal of the American Chemical Society - 28 Dec 2016

Rudolf Jeffrey D, Dong Liao-Bin, Manoogian Karina, Shen Ben

Abstract excerpt

Platensimycin (PTM) and platencin (PTN) are highly functionalized bacterial diterpenoid natural products that target bacterial and mammalian fatty acid synthases. PTM and PTN feature varying diterpene-derived ketolides that are linked to the same 3-amino-2,4-dihydroxybenzoic acid moiety. As a result, PTM is a selective inhibitor for FabF/FabB, while PTN is a dual inhibitor of FabF/FabB and FabH. We previously...

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Identifiers

PMID: 27966343
DOI: 10.1021/jacs.6b09818
PMCID: PMC5466352

Genes

PTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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