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Article

Non-coding single nucleotide variants affecting estrogen receptor binding and activity.

Genome medicine - 13 Dec 2016

Bahreini Amir, Levine Kevin, Santana-Santos Lucas, Benos Panayiotis V, Wang Peilu, Andersen Courtney, Oesterreich Steffi, Lee Adrian V

Abstract excerpt

BACKGROUND: Estrogen receptor (ER) activity is critical for the development and progression of the majority of breast cancers. It is known that ER is differentially bound to DNA leading to transcriptomic and phenotypic changes in different breast cancer models. We investigated whether single nucleotide variants (SNVs) in ER binding sites (regSNVs) contribute to ER action through changes in the ER cistrome,...

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Identifiers

PMID: 27964748
DOI: 10.1186/s13073-016-0382-0
PMCID: PMC5154163

Genes

GSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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