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Article

Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development.

Breast cancer research : BCR - 31 Jan 2011

Yu Jyh-Cherng, Hsiung Chia-Ni, Hsu Huan-Ming, Bao Bo-Ying, Chen Shou-Tung, Hsu Giu-Cheng, Chou Wen-Cheng, Hu Ling-Yueh, Ding Shian-Ling, Cheng Chun-Wen, Wu Pei-Ei, Shen Chen-Yang

Abstract excerpt

INTRODUCTION: Estrogen forms a complex with the estrogen receptor (ER) that binds to estrogen response elements (EREs) in the promoter region of estrogen-responsive genes, regulates their transcription, and consequently mediates physiological or tumorigenic effects. Thus, sequence variants in EREs have the potential to affect the estrogen-ER-ERE interaction. In this study, we examined the hypothesis that genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21281495
DOI: 10.1186/bcr2821
PMCID: PMC3109581

Genes

ESR1
NRCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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