Article

Oncogenic Potential and Molecular Disruptions of ESR2 Coding and UTRs Variants: An Integrative In Silico Analysis

2025-08-05

Abstract excerpt

(1) Background: Estrogen Receptor Beta 1 (ERβ1), encoded by the ESR2 gene, plays a key tumor-suppressive role in hormone-dependent cancers. However, the impact of nonsynonymous single-nucleotide polymorphisms (nsSNPs) and untranslated region (UTR) variants in ESR2 remains underexplored.; (2) Methods: We performed a comprehensive in silico analysis of high-risk pathogenic nsSNPs and UTR variants using genomic data...

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Literature Corpus work: a7061b16-5ed1-5eae-9fa2-300c32e10773
DOI: 10.20944/preprints202508.0204.v1

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