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Differentiation-Related Response to DNA Breaks in Human Mesenchymal Stem Cells

22 Jan 2013

Abstract excerpt

We have recently shown that the in vitro differentiation of human mesenchymal stem cells (hMSCs) was accompanied by an increased sensitivity toward apoptosis; however, the mechanism responsible for this shift is not known. Here, we show that the repair of DNA double-strand breaks (DSBs) was more rapid in undifferentiated hMSCs than in differentiated osteoblasts by quantification of the disappearance of γ-H2AX...

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PMID: 23341263
DOI: 10.1002/stem.1336

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