Article
Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis.
Naunyn-Schmiedeberg's archives of pharmacology - 1 Mar 2017
Fujimoto Yasuyuki, Azuma Yasu-Taka, Matsuo Yukiko, Kuwamura Mitsuru, Kuramoto Nobuyuki, Miki Mariko, Azuma Naoki, Teramoto Midori, Nishiyama Kazuhiro, Izawa Takeshi, Nakajima Hidemitsu, Takeuchi Tadayoshi
Abstract excerpt
Inflammatory bowel disease results from chronic dysregulation of the mucosal immune system and aberrant activation of both the innate and adaptive immune responses. IL-19 is a member of the IL-10 family, and IL-10 plays an important role in inflammatory bowel disease. We have previously shown that IL-19 knockout mice are more susceptible to innate-mediated colitis. Next, we ask whether IL-19 contributes to T...
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