Article
Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing.
Cell research - 1 Jun 2014
Yu Chang, Yu Jun, Yao Xiaotian, Wu William K K, Lu Youyong, Tang Senwei, Li Xiangchun, Bao Li, Li Xiaoxing, Hou Yong, Wu Renhua, Jian Min, Chen Ruoyan, Zhang Fan, Xu Lixia, Fan Fan, He Jun, Liang Qiaoyi, Wang Hongyi, Hu Xueda, He Minghui, Zhang Xiang, Zheng Hancheng, Li Qibin, Wu Hanjie, Chen Yan, Yang Xu, Zhu Shida, Xu Xun, Yang Huanming, Wang Jian, Zhang Xiuqing, Sung Joseph J Y, Li Yingrui, Wang Jun
Abstract excerpt
Single-cell sequencing is a powerful tool for delineating clonal relationship and identifying key driver genes for personalized cancer management. Here we performed single-cell sequencing analysis of a case of colon cancer. Population genetics analyses identified two independent clones in tumor cell population. The major tumor clone harbored APC and TP53 mutations as early oncogenic events, whereas the minor...
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