Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1 protein in canine degenerative myelopathy.

Research in veterinary science - 1 Mar 2021

Nakata Kohei, Namiki Mariko, Kobatake Yui, Nishida Hidetaka, Sakai Hiroki, Yamato Osamu, Urushitani Makoto, Maeda Sadatoshi, Kamishina Hiroaki

Abstract excerpt

Canine degenerative myelopathy (DM) is a fatal progressive neurodegenerative disease. Mutations in the superoxide dismutase 1 (SOD1) gene have been shown to be the major risk factor for DM, and it is hypothesized that neural degeneration is caused by a "gain of toxic function" of mutant SOD1. In this study, the spinal cord microRNA (miRNA) profiles of DM-affected dogs were investigated to elucidate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dog Diseases
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Neurodegenerative Diseases

Share to Protein Folding

Share to Spinal Cord

Share to Superoxide Dismutase-1

Share to Up-Regulation

Source

Identifiers

PMID: 33261827
DOI: 10.1016/j.rvsc.2020.11.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up-regulated spinal microRNAs induce aggregation of superoxide dismutase 1 protein in canine degenerative myelopathy.PMID 33261827Read ↗

Canine degenerative myelopathy.Semantic proximity Read ↗

Degenerative myelopathy in the Collie breed: a retrospective immunohistochemical analysis of superoxide dismutase 1 in an affected Rough Collie, and a molecular epidemiological survey of the SOD1: c.118G>A mutation in Japan.Semantic proximity Read ↗

The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond MovementSemantic proximity Read ↗

The inhibitory effects of MIF on accumulation of canine degenerative myelopathy-associated mutant SOD1 aggregation.Semantic proximity Read ↗

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS ModelsSemantic proximity Read ↗

The role of miRNA in motor neuron diseaseSemantic proximity Read ↗

An integrative miRNA-mRNA expression analysis identifies miRNA signatures associated with SOD1 and TARDBP patient-derived motor neuronsSemantic proximity Read ↗

Up-regulated inflammatory signatures of the spinal cord in canine degenerative myelopathy.Semantic proximity Read ↗

Non-coding RNAs and the deregulation of ubiquitin-proteasome network in neurodegeneration: a familia tria?Semantic proximity Read ↗

SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron.Semantic proximity Read ↗

MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)Semantic proximity Read ↗

Accumulation and aggregate formation of mutant superoxide dismutase 1 in canine degenerative myelopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.