Article
Molecular screening for the mutation associated with canine degenerative myelopathy (SOD1:c.118G > A) in German Shepherd dogs in Brazil.
PloS one - 1 Jan 2020
Santos Cássia Regina Oliveira, Gouveia João José de Simoni, Gouveia Gisele Veneroni, Bezerra Flávia Caroline Moreira, Nogueira Joel Fonseca, Baraúna Júnior Durval
Abstract excerpt
Canine Degenerative Myelopathy is a late onset recessive autosomal disease characterized by a progressive ascending degeneration of the spinal cord. Two causal mutations are associated with this disease: a transition (c.118G>A) in exon 2 of the SOD1 that was described in several breeds and a transversion (c.52A>T) in exon 1 of the same gene described in Bernese Mountain dogs. The aim of this study was to...
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