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Article

ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.

Biochemical and biophysical research communications - 22 Jan 2017

Mousa Jarrod J, Newsome Rachel C, Yang Ye, Jobin Christian, Bruner Steven D

Abstract excerpt

Multidrug transporters play key roles in cellular drug resistance to toxic molecules, yet these transporters are also involved in natural product transport as part of biosynthetic clusters in bacteria and fungi. The genotoxic molecule colibactin is produced by strains of virulent and pathobiont Escherichia coli and Klebsiella pneumoniae. In the biosynthetic cluster is a multidrug and toxic compound extrusion...

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PMID: 27939886
DOI: 10.1016/j.bbrc.2016.12.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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