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Article

Analysis of temozolomide resistance in low‐grade gliomas using a mechanistic mathematical model

9 Dec 2016

Abstract excerpt

Understanding how tumors develop resistance to chemotherapy is a major issue in oncology. When treated with temozolomide (TMZ), an oral alkylating chemotherapy drug, most low-grade gliomas (LGG) show an initial volume decrease but this effect is rarely long lasting. In addition, it has been suggested that TMZ may drive tumor progression in a subset of patients as a result of acquired resistance. Using...

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PMID: 27933657
DOI: 10.1111/fcp.12259

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