N-Terminal Chirality and Sequence Variations Modulate the Conformational Landscape of Amyloid-Beta 42.

Abstract excerpt

Amyloid beta (Aβ), one of the hallmark proteins of Alzheimer's disease (AD), aggregates into plaques that are strongly linked to cognitive decline and neuronal death. Reducing its aggregation propensity may provide a strategy to slow the progression of AD. While chirality modulation has emerged as an innovative approach to disrupt this process, research has primarily focused on alterations at the Cα position,...

Topics

• Amyloid beta-Peptides
• Molecular Dynamics Simulation
• Peptide Fragments
• Mutation
• Protein Conformation
• Amino Acid Sequence