Article

N-terminal Chirality and Sequence Variations Modulate the Conformational Landscape of Amyloid-beta 42 <sup>†</sup>

2026-03-22

Abstract excerpt

Amyloid beta (A β ), one of the hallmark proteins of Alzheimer’s Disease (AD), aggregates into plaques that are strongly linked to cognitive decline and neuronal death. Reducing its aggregation propensity may provide a strategy to slow the progression of AD. While chirality modulation has emerged as an innovative approach to disrupt this process, research has primarily focused on alterations at the Cα position,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa29c2cc-8af3-5120-959d-c669645bd558
DOI: 10.64898/2026.03.19.713039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

N-terminal Chirality and Sequence Variations Modulate the Conformational Landscape of Amyloid-beta 42 <sup>†</sup>DOI 10.64898/2026.03.19.713039Read

Alzheimer's protective A2T mutation changes the conformational landscape of the Aβ₁₋₄₂ monomer differently than does the A2V mutation.Semantic proximity Read

Emergence of Alternative Structures in Amyloid Beta 1-42 Monomeric Landscape by N-terminal Hexapeptide Amyloid Inhibitors.Semantic proximity Read

Familial Alzheimer A2 V mutation reduces the intrinsic disorder and completely changes the free energy landscape of the Aβ1-28 monomer.Semantic proximity Read

Dimerization Mechanism of Alzheimer Aβ40 Peptides: The High Content of Intrapeptide-Stabilized Conformations in A2V and A2T Heterozygous Dimers Retards Amyloid Fibril Formation.Semantic proximity Read

Weaker N-Terminal Interactions for the Protective over the Causative Aβ Peptide Dimer Mutants.Semantic proximity Read

Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.Semantic proximity Read

Effects of the Arctic (E22-->G) mutation on amyloid beta-protein folding: discrete molecular dynamics study.Semantic proximity Read

Impact of A2V Mutation and Histidine Tautomerism on Aβ42 Monomer Structures from Atomistic Simulations.Semantic proximity Read

Impact of the A2V Mutation on the Heterozygous and Homozygous Aβ1-40 Dimer Structures from Atomistic Simulations.Semantic proximity Read

Chemical mutagenesis for the modulation and study of protein function and dysfunction within Alzheimer's diseaseSemantic proximity Read

Alzheimer's Protective Cross-Interaction between Wild-Type and A2T Variants Alters Aβ42 Dimer Structure.Semantic proximity Read

The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.Semantic proximity Read