Article
Most ApoL1 Is Secreted by the Liver.
Journal of the American Society of Nephrology : JASN - 1 Apr 2017
Shukha Khuloud, Mueller Jessica L, Chung Raymond T, Curry Michael P, Friedman David J, Pollak Martin R, Berg Anders H
Abstract excerpt
Two coding sequence variants in the APOL1 gene (G1 and G2) explain much of the increased risk for FSGS, HIV-associated nephropathy, and hypertension-attributed ESRD among people of recent African ancestry. The ApoL1 protein is expressed in a wide variety of cell tissues. It has been assumed that the majority of circulating ApoL1 is produced by the liver, but this has not been shown. Using mass spectrometry, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.