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Article

Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Endorf Elizabeth B, Qing Hua, Aono Jun, Terami Naoto, Doyon Geneviève, Hyzny Eric, Jones Karrie L, Findeisen Hannes M, Bruemmer Dennis

Abstract excerpt

OBJECTIVE: Aberrant proliferation of smooth muscle cells (SMC) in response to injury induces pathological vascular remodeling during atherosclerosis and neointima formation. Telomerase is rate limiting for tissue renewal and cell replication; however, the physiological role of telomerase in vascular diseases remains to be determined. The goal of the present study was to determine whether telomerase reverse...

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Share to Chromatin Assembly and Disassembly
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to G1 Phase Cell Cycle Checkpoints

Share to Muscle, Smooth, Vascular

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Source

Identifiers

PMID: 27932351
DOI: 10.1161/ATVBAHA.116.308717

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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