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Molecular profiling of single circulating tumor cells with diagnostic intention

30 Oct 2014

Abstract excerpt

Several hundred clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but assays are lacking for comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for enrichment and isolation of pure CTCs with a non-random whole genome amplification method for single cells and applied it to 510 single CTCs and 189...

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PMID: 25358515
DOI: 10.15252/emmm.201404033

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