Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.

PloS one - 1 Jan 2014

Chang Diana, Gao Feng, Slavney Andrea, Ma Li, Waldman Yedael Y, Sams Aaron J, Billing-Ross Paul, Madar Aviv, Spritz Richard, Keinan Alon

Abstract excerpt

Many complex human diseases are highly sexually dimorphic, suggesting a potential contribution of the X chromosome to disease risk. However, the X chromosome has been neglected or incorrectly analyzed in most genome-wide association studies (GWAS). We present tailored analytical methods and software that facilitate X-wide association studies (XWAS), which we further applied to reanalyze data from 16 GWAS of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, X
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to DNA-Binding Proteins

Share to Molecular Chaperones

Share to Rho Guanine Nucleotide Exchange Factors

Share to Sex Characteristics

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 25479423
DOI: 10.1371/journal.pone.0113684
PMCID: PMC4257614

Genes

ARHGEF6
CENPI
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.PMID 25479423Read ↗

Accounting for eXentricities: Analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseasesSemantic proximity Read ↗

Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.Semantic proximity Read ↗

XWAS: a software toolset for genetic data analysis and association studies of the X chromosomeSemantic proximity Read ↗

X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans.Semantic proximity Read ↗

geneXplore: An Interactive Browser for X Chromosome-Wide Association Study ResultsSemantic proximity Read ↗

SeXY chromosomes and the immune system: reflections after a comparative studySemantic proximity Read ↗

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.Semantic proximity Read ↗

A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.Semantic proximity Read ↗

The impact of sex on the immune system explored at the single-cell levelSemantic proximity Read ↗

XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome.Semantic proximity Read ↗

The X in sex: how autoimmune diseases revolve around sex chromosomes.Semantic proximity Read ↗

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.