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Article

Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling

2 Feb 2015

Abstract excerpt

Recombinant adenoviral vectors (rAds) are lead vaccine candidates for protection against a variety of pathogens, including Ebola, HIV, tuberculosis, and malaria, due to their ability to potently induce T cell immunity in humans. However, the ability to induce protective cellular immunity varies among rAds. Here, we assessed the mechanisms that control the potency of CD8 T cell responses in murine models following...

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PMID: 25642773
DOI: 10.1172/jci78280

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