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Vaccines Based on Novel Adeno-Associated Virus Vectors Elicit Aberrant CD8+T-Cell Responses in Mice

23 Aug 2007

Abstract excerpt

We recently discovered an expanded family of adeno-associated viruses (AAVs) that show promise as improved gene therapy vectors. In this study we evaluated the potential of vectors based on several of these novel AAVs as vaccine carriers for human immunodeficiency virus type 1 Gag. Studies with mice indicated that vectors based on AAV type 7 (AAV7), AAV8, and AAV9 demonstrate improved immunogenicity in terms of...

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PMID: 17715240
DOI: 10.1128/jvi.01253-07

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