Article
Induction of neonatal TH1 and CTL responses by live viral vaccines: a role for replication patterns within antigen presenting cells?
Vaccine - 1 Jan 2000
Siegrist C A, Saddallah F, Tougne C, Martinez X, Kovarik J, Lambert P H
Abstract excerpt
Failure to generate CTL responses in early life has been linked to the preferential maturation of CD4 T cells into TH2 rather than TH1 cells in response to some, but not other, antigenic stimulations. Here, we provide preliminary evidence for the role of the viral replication pattern in the shapi...
Topics
- Animals
- Animals, Newborn
- Antigen-Presenting Cells
- Lymphocyte Activation
- Measles Vaccine
- Measles virus
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Respirovirus
- T-Lymphocytes, Cytotoxic
- Th1 Cells
- Th2 Cells
- Vaccines, Attenuated
- Viral Vaccines
- Virus Replication