Article
Induction of neonatal TH1 and CTL responses by live viral vaccines: a role for replication patterns within antigen presenting cells?
Vaccine - 1 Jan 2000
Siegrist C A, Saddallah F, Tougne C, Martinez X, Kovarik J, Lambert P H
Abstract excerpt
Failure to generate CTL responses in early life has been linked to the preferential maturation of CD4 T cells into TH2 rather than TH1 cells in response to some, but not other, antigenic stimulations. Here, we provide preliminary evidence for the role of the viral replication pattern in the shaping of neonatal cellular responses to live viral vaccines. Neonatal and early life immunization with live attenuated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.