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Article

Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway.

Virology journal - 11 Feb 2010

Hazari Sidhartha, Chandra Partha K, Poat Bret, Datta Sibnarayan, Garry Robert F, Foster Timothy P, Kousoulas Gus, Wakita Takaji, Dash Srikanta

Abstract excerpt

BACKGROUND: The sustained virological response to interferon-alpha (IFN-alpha) in individuals infected with hepatitis C virus (HCV) genotype 1 is only 50%, but is about 80% in patients infected with genotype 2-6 viruses. The molecular mechanisms explaining the differences in IFN-alpha responsiven...

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Identifiers

PMID: 20149251
DOI: 10.1186/1743-422X-7-36
PMCID: PMC2831880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20149251-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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