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Negative regulation of the interferon response by an interferon-induced long non-coding RNA

13 Aug 2014

Abstract excerpt

Long non-coding RNAs (lncRNAs) play critical roles in diverse cellular processes; however, their involvement in many critical aspects of the immune response including the interferon (IFN) response remains poorly understood. To address this gap, we compared the global gene expression pattern of primary human hepatocytes before and at three time points after treatment with IFN-α. Among ∼ 200 IFN-induced lncRNAs,...

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PMID: 25122750
DOI: 10.1093/nar/gku713

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