Article
Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation.
Scientific reports - 8 Dec 2016
Tammaro Alessandra, Kers Jesper, Emal Diba, Stroo Ingrid, Teske Gwendoline J D, Butter Loes M, Claessen Nike, Damman Jeffrey, Derive Marc, Navis Gerjan J, Florquin Sandrine, Leemans Jaklien C, Dessing Mark C
Abstract excerpt
Renal ischemia reperfusion (IR)-injury induces activation of innate immune response which sustains renal injury and contributes to the development of delayed graft function (DGF). Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory evolutionary conserved pattern recognition receptor expressed on a variety of innate immune cells. TREM-1 expression increases following acute and chronic...
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