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Article

Genetic and epigenetic characterization of the BRCA1 gene in Brazilian women at-risk for hereditary breast cancer.

Oncotarget - 10 Jan 2017

Felicio Paula Silva, Melendez Matias Eliseo, Arantes Lidia Maria Rebolho Batista, Kerr Ligia Maria, Carraro Dirce Maria, Grasel Rebeca Silveira, Campacci Natalia, Scapulatempo-Neto Cristovam, Fernandes Gabriela Carvalho, de Carvalho Ana Carolina, Palmero Edenir Inêz

Abstract excerpt

This study aimed to characterize women at-risk for hereditary BC regarding their clinical and molecular characteristics (mutation and methylation in the BRCA1 gene) and correlate the gene expression levels with histopathological, clinical and family history information. BRCA1 real time qPCR was performed to evaluate methylation status and gene expression. The study included 88 women grouped according to the BRCA1...

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Source

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Identifiers

PMID: 27926510
DOI: 10.18632/oncotarget.13750
PMCID: PMC5356847

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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