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Article

Prevalence of BRCA1 and BRCA2 genes promoter hypermethylation in breast cancer tissue.

Experimental oncology - 1 Mar 2021

Lobanova O E, Rossokha Z I, Medvedieva N L, Cheshuk V E, Vereshchako R I, Vershyhora V O, Fishchuk L Ye, Zakhartseva L M, Gorovenko N G

Abstract excerpt

BACKGROUND: Recent advances in the treatment of breast cancer (BC) have been related to the personalization of therapy. The methylation status of the promoter regions of tumor suppressor genes such as BRCA1 and BRCA2 is supposed to be useful as a prognostic factor in BC patients. AIM: To investigate the frequency of hypermethylation in the promoter regions of BRCA1 and BRCA2 genes in tumor tissue of BC patients,...

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Identifiers

PMID: 33785722
DOI: 10.32471/exp-oncology.2312-8852.vol-43-no-1.15703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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