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Article

rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment.

Scientific reports - 7 Dec 2016

Russo Annapina, Saide Assunta, Cagliani Roberta, Cantile Monica, Botti Gerardo, Russo Giulia

Abstract excerpt

5-FU is a chemotherapy drug commonly used for the treatment of human cancers; however drug resistance represents a major challenge for its clinical application. In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein stability leading to a decrease of CBS protein levels. rpL3 also regulates negatively the activation of NFκB by...

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Identifiers

PMID: 27924828
DOI: 10.1038/srep38369
PMCID: PMC5141482

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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