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Article

p53-Dependent anticancer effects of leptomycin B on lung adenocarcinoma.

Cancer chemotherapy and pharmacology - 1 Jun 2011

Shao Changxia, Lu Chuanwen, Chen Lixia, Koty Patrick P, Cobos Everardo, Gao Weimin

Abstract excerpt

PURPOSE: Leptomycin B (LMB) and/or its derivatives are considered a novel class of cancer therapeutics through blocking chromosome maintenance region 1, which mediates p53 nuclear export. The objectives of the present study were to first evaluate the cytotoxic effects of LMB on a normal human lung epithelial cell line (BEAS-2B) and three human lung adenocarcinoma cell lines with various p53 status (wild type:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inhibitor of Apoptosis Proteins

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Source

Identifiers

PMID: 20803015
DOI: 10.1007/s00280-010-1434-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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