Article
Growth inhibitory role of the p53 activator SCH 529074 in non‑small cell lung cancer cells expressing mutant p53.
Oncology reports - 1 Jun 2020
Nenkov Miljana, Ma Yunxia, Haase Daniela, Zhou Zhongwei, Li Yong, Petersen Iver, Lu Guanghua, Chen Yuan
Abstract excerpt
Mutations of p53 occur in approximately 50% of advanced non‑small cell lung cancer (NSCLC) cases, leading to loss of tumor suppressive function and/or gain of p53 oncogenic activity. Reactivation of mutant p53 and consequently induction of apoptosis in cancer cells is the goal of p53‑targeted therapy. Recently, several p53 mutant reactivating compounds were discovered including SCH 529074. However, the role of...
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