Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin.

Experimental cell research - 15 Nov 2017

Han Jia, Li Jie, Tang Kaijie, Zhang Huahua, Guo Bo, Hou Ni, Huang Chen

Abstract excerpt

Evidence demonstrate that p53 mutations and microRNAs (miRs) are important components of 5-FU resistance in colorectal cancer (CRC). miR-338-3p has been reported associated with cancer prognosis. However whether or not it influences chemotherapy sensitivity and the underlying mechanisms have not been elucidated. Here, three types of human colon cancer cell lines, HT29 (mutant p53), HCT116 (wild-type p53), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Fluorouracil

Share to HCT116 Cells

Share to HT29 Cells

Share to MicroRNAs

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 28928082
DOI: 10.1016/j.yexcr.2017.09.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin.PMID 28928082Read ↗

Decreased expression of miR‑3135b reduces sensitivity to 5‑fluorouracil in colorectal cancer by direct repression of PIM1Semantic proximity Read ↗

CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34Semantic proximity Read ↗

Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acidsSemantic proximity Read ↗

Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cellsSemantic proximity Read ↗

Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors.Semantic proximity Read ↗

MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signalingSemantic proximity Read ↗

Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cellsSemantic proximity Read ↗

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer TreatmentSemantic proximity Read ↗

Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to OxaliplatinSemantic proximity Read ↗

Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and updateSemantic proximity Read ↗

miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression.Semantic proximity Read ↗

MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.