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Article

B cell antigen extraction is regulated by physical properties of antigen-presenting cells.

The Journal of cell biology - 2 Jan 2017

Spillane Katelyn M, Tolar Pavel

Abstract excerpt

Antibody production and affinity maturation are driven by B cell extraction and internalization of antigen from immune synapses. However, the extraction mechanism remains poorly understood. Here we develop DNA-based nanosensors to interrogate two previously proposed mechanisms, enzymatic liberation and mechanical force. Using antigens presented by either artificial substrates or live cells, we show that B cells...

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Identifiers

PMID: 27923880
DOI: 10.1083/jcb.201607064
PMCID: PMC5223605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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