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Article

Podosomes of dendritic cells facilitate antigen sampling

1 Jan 2014

Abstract excerpt

Dendritic cells sample the environment for antigens and play an important role in establishing the link between innate and acquired immunity. Dendritic cells contain mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here, we...

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PMID: 24424029
DOI: 10.1242/jcs.141226

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