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Article

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction.

Nature communications - 5 Dec 2016

Hanebuth Marie A, Kityk Roman, Fries Sandra J, Jain Alok, Kriel Allison, Albanese Veronique, Frickey Tancred, Peter Christine, Mayer Matthias P, Frydman Judith, Deuerling Elke

Abstract excerpt

Hsp70 chaperones assist de novo folding of newly synthesized proteins in all cells. In yeast, the specialized Hsp70 Ssb directly binds to ribosomes. The structural basis and functional mode of recruitment of Ssb to ribosomes is not understood. Here, we present the molecular details underlying ribosome binding of Ssb in Saccharomyces cerevisiae. This interaction is multifaceted, involving the co-chaperone RAC and...

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Identifiers

PMID: 27917864
DOI: 10.1038/ncomms13695
PMCID: PMC5150220

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