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Article

Structural analysis of the ribosome-associated complex (RAC) reveals an unusual Hsp70/Hsp40 interaction.

The Journal of biological chemistry - 29 Jan 2010

Fiaux Jocelyne, Horst Janina, Scior Annika, Preissler Steffen, Koplin Ansgar, Bukau Bernd, Deuerling Elke

Abstract excerpt

Yeast Zuotin and Ssz are members of the conserved Hsp40 and Hsp70 chaperone families, respectively, but compared with canonical homologs, they atypically form a stable heterodimer termed ribosome-associated complex (RAC). RAC acts as co-chaperone for another Hsp70 to assist de novo protein folding. In this study, we identified the molecular basis for the unusual Hsp70/Hsp40 pairing using amide hydrogen exchange...

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Identifiers

PMID: 19920147
DOI: 10.1074/jbc.M109.075804
PMCID: PMC2823442

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