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Article

The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.

Nature communications - 16 Oct 2017

Mudholkar Kaivalya, Fitzke Edith, Prinz Claudia, Mayer Matthias P, Rospert Sabine

Abstract excerpt

The Hsp70 Ssb serves a dual role in de novo protein folding and ribosome biogenesis; however, the mechanism by which Ssb affects ribosome production is unclear. Here we establish that Ssb is causally linked to the regulation of ribosome biogenesis via the TORC1-Sch9 signaling pathway. Ssb is bound to Sch9 posttranslationally and required for the TORC1-dependent phosphorylation of Sch9 at T737. Also, Sch9 lacking...

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Identifiers

PMID: 29038496
DOI: 10.1038/s41467-017-00635-z
PMCID: PMC5643326

Genes

SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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