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Article

Functional characterization of the atypical Hsp70 subunit of yeast ribosome-associated complex.

The Journal of biological chemistry - 23 Nov 2007

Conz Charlotte, Otto Hendrik, Peisker Kristin, Gautschi Matthias, Wölfle Tina, Mayer Matthias P, Rospert Sabine

Abstract excerpt

Eukaryotic ribosomes carry a stable chaperone complex termed ribosome-associated complex consisting of the J-domain protein Zuo1 and the Hsp70 Ssz1. Zuo1 and Ssz1 together with the Hsp70 homolog Ssb1/2 form a functional triad involved in translation and early polypeptide folding processes. Strains lacking one of these components display slow growth, cold sensitivity, and defects in translational fidelity. Ssz1...

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PMID: 17901048
DOI: 10.1074/jbc.M706737200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional characterization of the atypical Hsp70 subunit of yeast ribosome-associated complex.PMID 17901048Read ↗

The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.Semantic proximity Read ↗

The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain.Semantic proximity Read ↗

Zuotin, a ribosome-associated DnaJ molecular chaperone.Semantic proximity Read ↗

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.Semantic proximity Read ↗

Structural analysis of the ribosome-associated complex (RAC) reveals an unusual Hsp70/Hsp40 interaction.Semantic proximity Read ↗

The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family.Semantic proximity Read ↗

Network of general and specialty J protein chaperones of the yeast cytosol.Semantic proximity Read ↗

Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.Semantic proximity Read ↗

The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.Semantic proximity Read ↗

Yeast Pdr13p and Zuo1p molecular chaperones are new functional Hsp70 and Hsp40 partners.Semantic proximity Read ↗

The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb.Semantic proximity Read ↗

Ribosome-associated complex binds to ribosomes in close proximity of Rpl31 at the exit of the polypeptide tunnel in yeast.Semantic proximity Read ↗

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