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Article

The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.

Nature structural & molecular biology - 1 Jun 2005

Huang Peggy, Gautschi Matthias, Walter William, Rospert Sabine, Craig Elizabeth A

Abstract excerpt

J-proteins are obligate partners of Hsp70s, forming a ubiquitous class of molecular chaperone machinery. The ribosome-associated Hsp70 of yeast Ssb binds nascent polypeptides as they exit the ribosome. Here we report that the ribosome-associated J-protein Zuo1 is the partner of Ssb. However, Zuo1 efficiently stimulates the ATPase activity of Ssb only when in complex with another Hsp70, Ssz1. Ssz1 binds ATP, but...

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PMID: 15908962
DOI: 10.1038/nsmb942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.PMID 15908962Read ↗

Functional characterization of the atypical Hsp70 subunit of yeast ribosome-associated complex.Semantic proximity Read ↗

The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain.Semantic proximity Read ↗

Zuotin, a ribosome-associated DnaJ molecular chaperone.Semantic proximity Read ↗

The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.Semantic proximity Read ↗

Structural analysis of the ribosome-associated complex (RAC) reveals an unusual Hsp70/Hsp40 interaction.Semantic proximity Read ↗

Network of general and specialty J protein chaperones of the yeast cytosol.Semantic proximity Read ↗

The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family.Semantic proximity Read ↗

Activation of pleiotropic drug resistance by the J-protein and Hsp70-related proteins, Zuo1 and Ssz1.Semantic proximity Read ↗

The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb.Semantic proximity Read ↗

The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.Semantic proximity Read ↗

Mutation of the ATP-binding pocket of SSA1 indicates that a functional interaction between Ssa1p and Ydj1p is required for post-translational translocation into the yeast endoplasmic reticulum.Semantic proximity Read ↗

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction.Semantic proximity Read ↗

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