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Article

Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins.

Molecular cell - 5 Jan 2017

Li Kai, Jiang Qiang, Bai Xue, Yang Yi-Feng, Ruan Mei-Yu, Cai Shi-Qing

Abstract excerpt

Tetrameric assembly of channel subunits in the endoplasmic reticulum (ER) is essential for surface expression and function of K+ channels, but the molecular mechanism underlying this process remains unclear. In this study, we found through genetic screening that ER-located J-domain-containing chaperone proteins (J-proteins) are critical for the biogenesis and physiological function of ether-a-go-go-related gene...

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Identifiers

PMID: 27916661
DOI: 10.1016/j.molcel.2016.10.027

Genes

ERG
DNAJB12
DNAJB14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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