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Article

The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel.

The Journal of biological chemistry - 21 Jun 2013

Buck Teresa M, Plavchak Lindsay, Roy Ankita, Donnelly Bridget F, Kashlan Ossama B, Kleyman Thomas R, Subramanya Arohan R, Brodsky Jeffrey L

Abstract excerpt

The epithelial sodium channel, ENaC, plays a critical role in maintaining salt and water homeostasis, and not surprisingly defects in ENaC function are associated with disease. Like many other membrane-spanning proteins, this trimeric protein complex folds and assembles inefficiently in the endop...

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Identifiers

PMID: 23645669
DOI: 10.1074/jbc.M113.469882
PMCID: PMC3689978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23645669-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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