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Article

Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties

18 Sept 2013

Abstract excerpt

The epithelial-mesenchymal transition (EMT) imparts metastatic competence on otherwise non-metastatic cancer cells through decreased inter-cellular adhesions, increased migratory capacity, stem cell properties and anoikis and chemotherapy resistance. In this study, we profiled changes in microRNA expression during EMT in conjunction with changes in DNA methylation at microRNA promoters to discover essential...

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PMID: 24045437
DOI: 10.1038/srep02687

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