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Article

Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.

Neuron - 21 Dec 2016

Kauwe Grant, Tsurudome Kazuya, Penney Jay, Mori Megumi, Gray Lindsay, Calderon Mario R, Elazouzzi Fatima, Chicoine Nicole, Sonenberg Nahum, Haghighi A Pejmun

Abstract excerpt

While beneficial effects of fasting on organismal function and health are well appreciated, we know little about the molecular details of how fasting influences synaptic function and plasticity. Our genetic and electrophysiological experiments demonstrate that acute fasting blocks retrograde synaptic enhancement that is normally triggered as a result of reduction in postsynaptic receptor function at the...

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Identifiers

PMID: 27916456
DOI: 10.1016/j.neuron.2016.10.063
PMCID: PMC5797711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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