Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impairment of fetal hematopoietic stem cell function in the absence of Fancd2.

Experimental hematology - 1 Apr 2017

Suzuki Sakiko, Racine Ronny R, Manalo Nathan A, Cantor Sharon B, Raffel Glen D

Abstract excerpt

Fanconi anemia (FA) results from mutations in the genes necessary for DNA damage repair and often leads to progressive bone marrow failure. Although the exhaustion of the bone marrow leads to cytopenias in FA patients as they age, evidence from human FA and mouse model fetal livers suggests that hematopoietic defects originate in utero, which may lead to deficient seeding of the bone marrow. To address this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Fanconi Anemia Complementation Group D2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Tissue Transplantation

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Mitomycin

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 27915139
DOI: 10.1016/j.exphem.2016.11.006
PMCID: PMC5362321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impairment of fetal hematopoietic stem cell function in the absence of Fancd2.PMID 27915139Read ↗

Fetal origins of hematopoietic failure in a murine model of Fanconi anemiaSemantic proximity Read ↗

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic StrategiesSemantic proximity Read ↗

Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1Semantic proximity Read ↗

In Utero Hematopoietic Stem Cell Transplant for Fanconi AnemiaSemantic proximity Read ↗

FANCA knockout in human embryonic stem cells causes a severe growth disadvantage.Semantic proximity Read ↗

In utero hematopoietic stem cell transplantation for Fanconi anemiaSemantic proximity Read ↗

Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell ProliferationSemantic proximity Read ↗

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.Semantic proximity Read ↗

A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.Semantic proximity Read ↗

Comprehensive characterization of mesenchymal stromal cells from patients with Fanconi anaemia.Semantic proximity Read ↗

Germ cell defects and hematopoietic hypersensitivity to gamma- interferon in mice with a targeted disruption of the Fanconi anemia C geneSemantic proximity Read ↗

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.